Design, synthesis and protein-targeting properties of thioether-linked hydrogen bond surrogate helices.
نویسندگان
چکیده
Appropriately-placed hydrogen bond surrogates have been demonstrated to efficiently nucleate helical conformations. Herein we describe an efficient method for the synthesis of thioether-based hydrogen bond surrogate (teHBS) helices. A teHBS helix is shown to adopt a stable conformation and target its cognate protein receptor with high affinity.
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ورودعنوان ژورنال:
- Chemical communications
دوره 48 10 شماره
صفحات -
تاریخ انتشار 2012